• Can Vet J · Oct 2015

    Randomized Controlled Trial

    Effects of administration of a synthetic low molecular weight/low molar substitution hydroxyethyl starch solution in healthy neonatal foals.

    • Kate L Hepworth-Warren, David M Wong, Bonnie L Hay-Kraus, Chong Wang, and Yaxuan Sun.
    • Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
    • Can Vet J. 2015 Oct 1; 56 (10): 1069-74.

    AbstractThis study compared the effects of IV administration of isotonic fluid therapy and colloidal fluid therapy in healthy neonatal foals. Fifteen healthy neonatal foals were used in a randomized blinded prospective clinical study. Foals were randomly assigned to receive a bolus of 20 mL/kg of tetrastarch (TES) or balanced crystalloid solution. Vital parameters, colloid osmotic pressure (COP), and various clinicopathologic variables were assessed prior to infusion and at various time points up to 120 h after infusion. The treatment group (TES) had a significant increase in both COP and percentage increase in COP at 1 and 3 h. The COP was significantly lower than baseline at 3 h in the control group. No significant changes were observed in coagulation parameters in either group. Tetrastarch was effective in increasing COP for 3 h after infusion and had no notable adverse clinical effects in this group of healthy foals. Further studies are warranted regarding optimal dosing and effects in clinically ill foals.

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