• Sofie M Adriaanse, Ernesto J Sanz-Arigita, Maja A A Binnewijzend, Rik Ossenkoppele, Nelleke Tolboom, Daniëlle M E van Assema, Alle Meije Wink, Ronald Boellaard, Maqsood Yaqub, Albert D Windhorst, Wiesje M van der Flier, Philip Scheltens, Adriaan A Lammertsma, Serge A R B Rombouts, Frederik Barkhof, and Bart N M van Berckel.
• Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
• Hum Brain Mapp. 2014 Mar 1;35(3):779-91.

AbstractThe purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.Copyright © 2012 Wiley Periodicals, Inc.

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