• Clinics in perinatology · Sep 2012

    Review

    Clinical effectiveness and safety of permissive hypercapnia.

    • Julie Ryu, Gabriel Haddad, and Waldemar A Carlo.
    • Department of Pediatrics, Rady Children's Hospital, University of California San Diego, 9500 Gilman Drive, MC 0735, La Jolla, CA 92093, USA.
    • Clin Perinatol. 2012 Sep 1;39(3):603-12.

    AbstractExperimental and clinical data indicate that ventilator strategies with permissive hypercapnia may reduce lung injury by a variety of mechanisms. Seven randomized controlled trials in preterm neonates suggest that permissive hypercapnia started early, before the initiation of mechanical ventilation (in conjunction with continuous positive airway pressure), followed by prolonged permissive hypercapnia if mechanical ventilation is needed is an alternative to early ventilation and surfactant. Permissive hypercapnia may improve pulmonary outcomes and survival.Copyright © 2012 Elsevier Inc. All rights reserved.

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