• Injury · Jan 1994

    The prevention of infection in open fractures: an experimental study of the effect of fracture stability.

    • P Worlock, R Slack, L Harvey, and R Mawhinney.
    • University Hospital, Nottingham, UK.
    • Injury. 1994 Jan 1;25(1):31-8.

    AbstractAn experimental model of a contaminated open fracture has been developed. This model has been used to test the hypothesis that stable fixation of a contaminated open fracture will reduce its susceptibility to infection. The tibiae of male New Zealand white rabbits were fractured and then fixed with either a dynamic compression plate (stable group) or a loose-fitting intramedullary rod (unstable group). The fracture site was then inoculated with a standard inoculum of Staphylococcus aureus. There were 20 rabbits in the stable group and osteomyelitis developed in seven (35 per cent); in the unstable group 15 (71 per cent) out of 21 animals developed osteomyelitis. This difference in infection rates was statistically significant (P < 0.02). This experimental study supports the concept of stabilization of open fractures in man.

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