• Plos One · Jan 2012

    Clinical manifestations and case management of Ebola haemorrhagic fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008.

    • Paul Roddy, Natasha Howard, Maria D Van Kerkhove, Julius Lutwama, Joseph Wamala, Zabulon Yoti, Robert Colebunders, Pedro Pablo Palma, Esther Sterk, Benjamin Jeffs, Michel Van Herp, and Matthias Borchert.
    • Medical Departments of Médecins Sans Frontières, Barcelona, Spain. roddypd@gmail.com
    • Plos One. 2012 Jan 1;7(12):e52986.

    AbstractA confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect.

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