• Virender K Sharma, Cuong C Nguyen, Michael D Crowell, David A Lieberman, Patricia de Garmo, and David E Fleischer.
• Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Scottsdale, Arizona 85259, and Oregon Health Sciences University, Portland, Oregon, USA.
• Gastrointest. Endosc. 2007 Jul 1;66(1):27-34.

BackgroundCardiopulmonary unplanned events (CUE) related to conscious sedation constitute a major proportion of GI endoscopy-associated complications.ObjectivesOur purpose was to study the incidence of CUE during GI endoscopy and to determine factors that may predict CUE.DesignRetrospective CORI (Clinical Outcomes Research Initiative) database review.PatientsUndergoing GI endoscopy under conscious sedation.Main Outcome MeasurementCUE associated with GI endoscopy.ResultsData on 324,737 unique procedures (EGD, 140,692; colonoscopy, 174,255; ERCP, 6092; and EUS, 3698) performed with the patient under conscious sedation were analyzed. Unplanned events were reported in 1.4% of procedures; 0.9% were associated with CUE. Rates of CUE with EGD, colonoscopy, ERCP, and EUS were 0.6%, 1.1%, 2.1%, and 0.9%, respectively. Multiple logistic regression revealed patient age (odds ratio [OR] 1.02, 95% CI 1.01-1.02) and ASA class were significant predictors of CUE (OR compared with ASA I: ASA II 1.05, 95% CI 0.95-1.16; ASA III 1.8, 95% CI 1.6-2.0, ASA IV 3.2, 95% CI 2.5-4.1, ASA V 7.5; 95% CI 3.2-17.6). Inpatient procedures were associated with higher CUE (OR 1.5, 95% CI 1.3-1.7). Compared with universities, nonuniversity sites (OR 1.2, 95% CI 1.1-1.4) and Veterans Administration Medical Centers (OR 1.4, 95% CI 1.2-1.5) had significantly higher CUE. Use of supplemental oxygen during a procedure was associated with significantly more CUE (OR 1.2, 95% CI 1.1-1.3). Involvement of a trainee with a procedure was also associated with higher CUE (OR 1.3, 95% CI 1.1-1.4).LimitationsRetrospective review of data entered voluntarily by endoscopists not trained on CORI data entry.ConclusionsDuring GI endoscopy with conscious sedation, patient's age, higher ASA grade, inpatient status, trainee participation, and routine use of oxygen are associated with a higher incidence of CUE.

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