• Brain research · Oct 1999

    Increased expression of growth-associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced cystitis.

    • M A Vizzard and M M Boyle.
    • Departments of Neurology and Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA. mvizzard@zoo.uvm.edu
    • Brain Res. 1999 Oct 9;844(1-2):174-87.

    AbstractAlterations in the expression of growth-associated protein 43 (GAP-43) were examined in lower urinary tract micturition reflex pathways in a chronic model of cyclophosphamide (CYP)-induced cystitis. In control animals, expression of GAP-43 was present in specific regions of the gray matter in the rostral lumbar and caudal lumbosacral spinal cord, including: (1) the dorsal commissure; (2) the dorsal horn and (3) the regions of the intermediolateral cell column (L1-L2) and the sacral parasympathetic nucleus (L6-S1) and (4) in the lateral collateral pathway of Lissauer in L6-S1 spinal segments. Densitometry analysis has demonstrated significant increases (p

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