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Case Reports
Generalized tonic-clonic seizures in adult patients following intravenous administration of desmopressin.
- Jiamei Guo, Dan Wang, Kebin Zeng, Guangyan Xu, and Yungping Zhao.
- Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong County, Chongqing 400016, China.
- Aging Clin Exp Res. 2013 Aug 1;25(4):479-81.
AbstractDesmopressin is a synthetic replacement for vasopressin, which is used to reduce perioperative blood loss. However, seizure attacks were observed in patients after administration of desmopressin. Here, we reported two cases of adult Chinese patients experienced generalized tonic-clonic seizures associated with severe hyponatremia caused by intravenously administered desmopressin after surgery. The patients' neurological conditions returned to baseline quickly and completely following discontinuation of desmopressin, control of the seizures, and fluid intake restriction. These cases illustrate the importance of periodic monitoring of electrolyte concentrations and fluid intake during use of desmopressin.
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