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Pediatr. Infect. Dis. J. · Aug 2004
Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis.
- Lise E Nigrovic, Nathan Kuppermann, Alexander J McAdam, and Richard Malley.
- Division of Emergency Medicine, Children's Hospital, Boston, MA, USA.
- Pediatr. Infect. Dis. J. 2004 Aug 1; 23 (8): 786-8.
AbstractWe conducted a 10-year retrospective study of all children who had cerebrospinal fluid latex agglutination testing for bacterial antigens performed at 1 tertiary care urban children's hospital. Of the 176 patients with culture-negative meningitis who were pretreated with antibiotics before lumbar puncture, none had a positive latex agglutination study (0 of 176; 95% confidence interval, 0-2%). Latex agglutination studies identified no additional cases of bacterial meningitis beyond those identified by culture in pretreated patients. Clinical decision-making algorithms for the management of pretreated patients at risk for bacterial meningitis should not include latex agglutination testing.
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