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Pediatr Crit Care Me · Mar 2004
Case ReportsTerlipressin bolus induces systemic vasoconstriction in septic shock.
- Mark J Peters, Rachelle A Booth, and Andy J Petros.
- Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.
- Pediatr Crit Care Me. 2004 Mar 1; 5 (2): 112-5.
ObjectiveTo report the use of a synthetic, long-acting, vasopressin analog, terlipressin, as an effective vasoconstrictor in septic shock.DesignCase report.SettingA 22-bed pediatric intensive care unit in a tertiary referral center.PatientAn 11-yr-old male with multiple-organism Gram-negative septic shock with high normal cardiac output as assessed by pulse contour analysis and low systemic vascular resistance despite norepinephrine infusion.InterventionTwo peripherally administered doses of terlipressin (0.5 mg).Measurements And Main ResultsEach dose of terlipressin was associated with a rapid increase in systemic vascular resistance, despite weaning and discontinuation of norepinephrine infusion from 0.15 microg.kg(-1).min(-1) lasting approximately 6 hrs.ConclusionTerlipressin may be useful for sepsis-induced vasodilation.
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