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J Clin Psychopharmacol · Oct 2010
Case ReportsVenlafaxine-associated serotonin syndrome causing severe rhabdomyolysis and acute renal failure in a patient with idiopathic Parkinson disease.
- Senaka Rajapakse, Lakshan Abeynaike, and Thanushi Wickramarathne.
- Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka. senaka.ucfm@gmail.com
- J Clin Psychopharmacol. 2010 Oct 1; 30 (5): 620-2.
AbstractA 43-year-old male patient with idiopathic Parkinson disease, on dopaminergic therapy, was admitted with confusion and agitation, diaphoresis, and hyperkinesia after the commencement of the serotonin-noradrenaline reuptake inhibitor venlafaxine 2 weeks prior for depression. He was found to have severe rhabdomyolysis and developed acute renal failure. The most likely diagnosis was serotonin syndrome induced by venlafaxine, although neuroleptic malignant syndrome was also considered. The differential diagnosis, atypical features in this presentation, and possible mechanisms are discussed.
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