• Michelle M Isley, Jeffrey T Jensen, Mark D Nichols, Amy Lehman, Paula Bednarek, and Alison Edelman.
• Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA. Michelle.Isley@osumc.edu
• Contraception. 2012 Mar 1; 85 (3): 275-81.

BackgroundThe study was conducted to examine the effects of a 4% intrauterine lidocaine infusion on patient-perceived pain during transcervical sterilization.Study DesignThis was a randomized, double-blind, placebo-controlled trial. Subjects received standard premedication with 800 mg ibuprofen, 2 mg lorazepam, a 10-mL 1% lidocaine paracervical block and transcervical instillation of 5 mL of either 4% lidocaine or saline 3 min prior to insertion of the hysteroscope. Subjects completed a series of 100-mm visual analog scales to measure their perceived pain at set time points during and after the procedure. Serum lidocaine levels were obtained in a subset of subjects.ResultsPain scores at all evaluation points did not significantly differ between groups (lidocaine n=29, saline n=29). Mean lidocaine levels did not differ between groups, and no subject demonstrated symptoms of lidocaine toxicity. The highest serum lidocaine level (4022 ng/mL) occurred 20 min after infusion in a lidocaine-treated subject.ConclusionIntrauterine lidocaine prior to outpatient transcervical sterilization does not decrease pain.Copyright © 2012 Elsevier Inc. All rights reserved.

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