• Medical hypotheses · Oct 2012

    Methoxetamine: from drug of abuse to rapid-acting antidepressant.

    • M Coppola and R Mondola.
    • Department of Addiction, ASL CN2, Viale Coppino 46, 12051 Alba (CN), Italy. coppolamail@alice.it
    • Med. Hypotheses. 2012 Oct 1; 79 (4): 504-7.

    AbstractMethoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and other arylcyclohexylamine compounds, methoxetamine is thought to be both a noncompetitive NMDA receptor antagonist and a dopamine reuptake inhibitor. Furthermore, it acts as an agonist at dopamine D2, serotonin 5HT2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. The hypothesis is that methoxetamine can produce rapid antidepressant effects in patients with resistant and non-resistant unipolar and bipolar depression.Copyright © 2012 Elsevier Ltd. All rights reserved.

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