• Xiang Huo, Guoqing Shi, Xinxu Li, Xuehui Lai, Liquan Deng, Feng Xu, Mingquan Chen, Qiang Wei, Thomas Samba, and Xiaofeng Liang.
• Department of Acute Infectious Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, China.
• Vaccine. 2016 Apr 4; 34 (15): 1767-72.

BackgroundClinical trials of Ebola vaccine are ongoing. Before it becomes commercially available, understanding the Ebola vaccine-related knowledge and attitude of the general population is imperative to developing an effective vaccine coverage strategy.MethodsWe conducted a survey including 400 participants from general communities of the West Area Rural District, Sierra Leone. Knowledge and attitudes about Ebola vaccine were investigated, and the determinants of having knowledge and a positive attitude toward accepting vaccination were identified.ResultsOver half (55.8%) of the participants were aware of Ebola vaccine. About 60% of the participants were willing to be study subjects if the Ebola vaccine clinical trial were conducted in their communities. Most of the participants (72.5%) were willing to take Ebola vaccination if it was free of charge. Given that the vaccination was not free, the proportion willing to pay a fee to take the vaccination declined dramatically to 26.6%. Using a forward step-wise logistic model, monthly salary was identified as the single determinant (OR for every 100,000 Leones increase: 1.17, 95%CI: 1.04-1.31) for awareness of Ebola vaccine, which was identified as the determinant (OR: 1.88, 95%CI: 1.17-3.02) for free vaccination uptake willingness. The combination of monthly salary, monthly average income of family members and their interaction was found to be associated with charged vaccination uptake willingness.DiscussionMeasures are still needed to promote the Ebola vaccine awareness and knowledge updating. Free or low-priced vaccine could increase the vaccination acceptability of the general community population significantly.Copyright © 2016 Elsevier Ltd. All rights reserved.

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