-
- C A Hirshman, A Malley, and H Downes.
- J. Appl. Physiol. 1980 Dec 1; 49 (6): 953-7.
AbstractBronchial inhalation challenges to Ascaris suum, citric acid, and methacholine were performed in eight Basenji-Greyhound (BG) crossbreed dogs, five of which were reactive to Ascaris antigen aerosols (AAA). Responses to aerosol challenges were measured as changes in pulmonary resistance (RL) and dynamic compliance (Cdyn) and were compared to responses obtained in five mongrel dogs. Responses to methacholine and citric acid were similar in BG dogs whether Ascaris-sensitive or not, but BG dogs were clearly more reactive than mongrels to both types of nonspecific challenge. Methacholine responses were elicited at 10-30 times lower concentrations in BG dogs than in mongrels; 10% citric acid, which failed to elicit any response in mongrels, increased RL 5- to 10-fold in BG dogs. We conclude that the BG dog demonstrates nonspecific bronchial hyperreactivity, as in human asthma.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..