• Pari Azari, Yan Lu, Colin F M Clarke, Timothy Collins, Dean Briones, and Billy Huh.
• Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA. pari.azari@gmail.com
• Neuromodulation. 2011 Sep 1; 14 (5): 428-31; discussion 431.

Objective  To determine if there is a relationship in our patient developing complex regional pain syndrome from a jellyfish and its subsequent spread to the contralateral side.Methods  Data bases were searched using PubMed and Ovid. Keywords searched include "complex regional pain syndrome,"jelly fish," and "pathophysiology."Results  This patient was successfully treated with a spinal cord stimulator implantation with bilateral lead placement at thoracic spine (T9) stimulating her lower extremities in addition to the leads that had already been placed in her cervical spine for her upper extremities.Conclusion  Definite knowledge of the pathophysiology of complex regional pain syndrome would allow better identification of risk factors for the development of this condition after trauma. This patient is at higher risk of developing complex regional pain syndrome and should avoid surgeries (such as knee and wrist surgeries) and high risk physical activities.© 2011 International Neuromodulation Society.

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