• Anesthesia and analgesia · Jun 2015

    Randomized Controlled Trial

    The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval.

    • John Dingley, Xun Liu, Hannah Gill, Elisa Smit, Hemmen Sabir, James Tooley, Ela Chakkarapani, David Windsor, and Marianne Thoresen.
    • From the *College of Medicine, Swansea University, Wales, United Kingdom; †Neonatal Neuroscience, School of Clinical Science, University of Bristol, Bristol, United Kingdom; ‡Neonatal Intensive Care Unit and §Anaesthetic Department, University Hospital Bristol, Bristol, United Kingdom; and the ∥Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
    • Anesth. Analg.. 2015 Jun 1;120(6):1331-6.

    BackgroundTherapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.MethodsDuring a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.ResultsWithout xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).ConclusionsXenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.

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