• Martijn D de Kruif, Maarten Limper, Karlien Sierhuis, Jiri F P Wagenaar, C Arnold Spek, Cecilia Garlanda, Alessia Cotena, Alberto Mantovani, Hugo ten Cate, Pieter H Reitsma, and Eric C M van Gorp.
• Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. m.d.dekruif@amc.uva.nl
• J. Infect. 2010 Feb 1; 60 (2): 122-7.

ObjectivesThe long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department.MethodsLevels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure.ResultsIn comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81).ConclusionsPTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department.Copyright 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

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