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Bioorg. Med. Chem. Lett. · Mar 2007
Butyl 2-(4-[1.1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain.
- Anne-Marie Liberatore, Jocelyne Schulz, Christine Favre-Guilmard, Jacques Pommier, Jacques Lannoy, Emilia Pawlowski, Marie-Anne Barthelemy, Marion Huchet, Michel Auguet, Pierre-Etienne Chabrier, and Dennis Bigg.
- Ipsen Research Laboratories, Institut Henri Beaufour, 5 avenue du Canada, 91966 Les Ulis Cedex, France. anne-marie.liberatore@ipsen.com
- Bioorg. Med. Chem. Lett. 2007 Mar 15; 17 (6): 1746-9.
AbstractA series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.
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