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- Stephen J Loughran, Elizabeth A Kruse, Douglas F Hacking, Carolyn A de Graaf, Craig D Hyland, Tracy A Willson, Katya J Henley, Sarah Ellis, Anne K Voss, Donald Metcalf, Douglas J Hilton, Warren S Alexander, and Benjamin T Kile.
- Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.
- Nat. Immunol. 2008 Jul 1; 9 (7): 810-9.
AbstractEts-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
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