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- Sharan K Bagal, Mark L Chapman, Brian E Marron, Rebecca Prime, R Ian Storer, and Nigel A Swain.
- Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, UK. Electronic address: sharan.bagal@pfizer.com.
- Bioorg. Med. Chem. Lett. 2014 Aug 15; 24 (16): 3690-9.
AbstractVoltage-gated sodium channels (Navs) are an important family of transmembrane ion channel proteins and Nav drug discovery is an exciting field. Pharmaceutical investment in Navs for pain therapeutics has expanded exponentially due to genetic data such as SCN10A mutations and an improved ability to establish an effective screen sequence for example IonWorks Barracuda®, Synchropatch® and Qube®. Moreover, emerging clinical data (AZD-3161, XEN402, CNV1014802, PF-05089771, PF-04531083) combined with recent breakthroughs in Nav structural biology pave the way for a future of fruitful prospective Nav drug discovery.Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
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