• Eri Sato, Kazuko Nagano, Noriko Akasaka, Satoshi Manaka, and Takeshi Tateda.
• Department of Anesthesiology, St. Marianna University, Yokohama City Seibu Hospital, Yokohama 241-0811.
• Masui. 2003 Oct 1; 52 (10): 1062-5.

BackgroundSevoflurane is known as a useful and safe anesthetic because of its properties of fast uptake and elimination at the lungs and of no effects on hepatic function. In this study we examined the effect of repeated sevoflurane anesthesia on hepatic function and immunological system.MethodsEight patients (ASA, PS 2 or 3) received sevoflurane anesthesia three times in 6 months. Six patients had emergency operation for injuries. Aspirate transaminase (AST), alanine transaminase (ALT) and complements (CH50, C3, C4) were measured prior to anesthesia, and 1, 7 and 14 days after anesthesia.ResultsThe values of AST and ALT were high prior to anesthesia at the first anesthesia. However, these were of no significant changes. CH50, C3, C4 increased significantly after the first anesthesia. However, there were no significant changes of these complements after the second and the third anesthesia.ConclusionsOur results suggest that sevoflurane is not likely to provide adverse effects on the liver and to suppress the production of complements accompanied by the surgical stress.

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