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Bioorg. Med. Chem. Lett. · Mar 2008
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.
- Liming Shao, Michael Hewitt, Thomas P Jerussi, Frank Wu, Scott Malcolm, Paul Grover, Kevin Fang, Patrick Koch, Chris Senanayake, Nandkumar Bhongle, Seth Ribe, Roger Bakale, and Mark Currie.
- Sepracor Inc., Medicinal Chemistry, 84 Waterford Drive, Marlborough, MA 01752, USA. Liming.shao@sepracor.com
- Bioorg. Med. Chem. Lett. 2008 Mar 1; 18 (5): 1674-80.
AbstractTramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.
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