• Liu-Qun Jia, Yong-Chun Shen, Qian-Jing Hu, Chun Wan, Tao Wang, Lei Chen, and Fu-Qiang Wen.
• Division of Medicine, West China Hospital of Sichuan University, Sichuan, Chengdu, China.
• J. Int. Med. Res. 2013 Aug 1; 41 (4): 934-43.

ObjectiveThe aim of the present study was to establish the predictive values of neutrophil CD64 expression in diagnosing neonatal infection.MethodsA comprehensive search of the PubMed and Embase® literature databases identified outcome data from published studies estimating the diagnostic accuracy of neutrophil CD64 expression for neonatal infection. Summary estimates for sensitivity, specificity, diagnostic odds ratios (DOR) and the area under the summary receiver operating characteristic curve (AUC) were calculated using a bivariate random-effects approach.ResultsTwelve studies including 1915 neonates were analysed. Summary estimates (95% confidence intervals) for CD64 expression in the diagnosis of neonatal infection were: sensitivity, 0.78 (0.75, 0.81); specificity, 0.81 (0.78, 0.83); DOR, 21.27 (11.71, 38.65); positive-likelihood ratio, 4.53 (3.22, 6.36); negative-likelihood ratio, 0.23 (0.14, 0.37); AUC, 0.89.ConclusionsNeutrophil CD64 expression can be used as an additional test in the diagnosis of neonatal infection. Results of a CD64 assay should not be used alone to diagnose such infections, but should be interpreted in combination with other test results and clinical findings.

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