• Takefumi Nikaido, Yoshinori Tanino, Xintao Wang, Suguru Sato, Kenichi Misa, Naoko Fukuhara, Yuki Sato, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Tetsuhito Kojima, Mishie Tanino, Yuichi Endo, Kohsuke Tsuchiya, Ikuo Kawamura, Charles W Frevert, and Mitsuru Munakata.
• Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima.
• J. Infect. Dis. 2015 Nov 1; 212 (9): 1500-8.

BackgroundSyndecan-4 is a transmembrane heparan sulfate proteoglycan expressed in a variety of cells, and glycosaminoglycan side chains of syndecan-4 bind to several proteins, suggesting several biological functions. However, the role of syndecan-4 in acute bacterial pneumonia has not yet been elucidated.MethodsSerum syndecan-4 levels were measured in patients with acute pneumonia, and the relationships between serum syndecan-4 levels and clinical parameters were analyzed. Next, we treated wild-type and syndecan-4-deficient mice with Streptococcus pneumoniae intranasally and analyzed the phenotype of syndecan-4-deficient mice.ResultsIn the patients with acute pneumonia, serum syndecan-4 levels were significantly higher than in the healthy volunteers and correlated negatively with the pneumonia severity score. In addition, in patients who improved with short-term antibiotic therapy, serum syndecan-4 levels were higher on admission and gradually increased during antibiotic therapy. Furthermore, in syndecan-4-deficient mice, the survival rate was significantly worse, and total neutrophil counts in bronchoalveolar lavage fluid, bacterial counts in blood, and plasma levels of inflammatory cytokines were significantly higher than in wild-type mice.ConclusionsThese results suggest that syndecan-4 has an anti-inflammatory function in acute pneumonia and could serve as a useful biomarker in these patients.© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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