• Pain Res Manag · Jul 2009

    Review Historical Article

    Herpes zoster and postherpetic neuralgia: past, present and future.

    • Gary J Bennett and C Peter N Watson.
    • Department of Anesthesia, Faculty of Dentistry, and The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada. gary.bennett@mcgill.ca
    • Pain Res Manag. 2009 Jul 1; 14 (4): 275282275-82.

    AbstractThe history behind the current understanding of the varicella-zoster virus and its relationship to the pain conditions caused by shingles and postherpetic neuralgia are reviewed. The framework for the current conceptualization is Hope-Simpson's latency hypothesis. Data from recent work in virology, neuroanatomy and epidemiology are reviewed, as is work using varicella-zoster virus-infected animals. The recent data largely confirm Hope-Simpson's hypothesis and extend it significantly.

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