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Bioorg. Med. Chem. Lett. · Aug 2007
N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.
- Christopher Deur, Arun K Agrawal, Heidi Baum, John Booth, Susan Bove, Joan Brieland, Amy Bunker, Cleo Connolly, Joseph Cornicelli, JoAnn Dumin, Barry Finzel, Xinmin Gan, Sheila Guppy, Gregg Kamilar, Kenneth Kilgore, Pil Lee, Cho-Ming Loi, Zhen Lou, Mark Morris, Laurence Philippe, Sally Przybranowski, Frank Riley, Brian Samas, Brian Sanchez, Haile Tecle, Ziqiang Wang, Kathryn Welch, Michael Wilson, and Karen Yates.
- Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. christopher.deur@pfizer.com
- Bioorg. Med. Chem. Lett. 2007 Aug 15; 17 (16): 4599-603.
AbstractIt has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the treatment of stroke, was evaluated and further optimized with the goal of finding peripherally restricted NMDA receptor antagonists.
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