• Trustin S Domes, Patrick H D Colquhoun, Brian Taylor, Jonathan I Izawa, Andrew A House, and Patrick P W Luke.
• Division of Urology, Department of Medicine, Schulich School of Medicine, University of Western Ontario, London, Ontario.
• Can J Surg. 2011 Dec 1; 54 (6): 387-93.

BackgroundTo perform complete resection of locally advanced and recurrent rectal carcinoma, total pelvic exenteration (TPE) may be attempted. We identified disease-related outcomes and prognostic factors.MethodsWe conducted a single-centre review of patients who underwent TPE for rectal carcinoma over a 10-year period.ResultsWe included 28 patients in our study. After a median follow-up of 35 months, 53.6% of patients were alive with no evidence of disease. The 3-year actuarial disease-free and overall survival rates were 52.2% and 75.1%, respectively. On univariate analysis, recurrent disease, preoperative body mass index greater than 30 and lymphatic invasion were poor prognostic factors for disease-free survival, and only lymphatic invasion predicted overall survival. Additionally, multivariate analysis identified lymphatic invasion as an independent poor prognostic factor for disease-free survival in this patient population with locally advanced and recurrent rectal carcinoma.ConclusionDespite the significant morbidity, TPE can provide long-term survival in patients with rectal carcinoma. Additionally, lymphatic invasion on final pathology was an independent prognostic factor for disease-free survival.

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