Low-molecular-weight heparins for the prevention and

J Reprod Med · Sep 2008

Low-molecular-weight heparins for the prevention and treatment of venous thromboembolism in at-risk pregnant women: a review.

Certain pregnant populations are at high risk of developing venous thromboembolism (VTE) during pregnancy. Patients at particularly high risk of VTE are those with a history of VTE, thrombophilia or adverse pregnancy outcomes or with mechanical heart valves. ⋯ Low-molecular-weight heparin (LMWH) is a safe and effective thromboprophylaxis option in these patients and has a number of administrative and pharmacokinetic advantages over unfractionated heparin. Furthermore, LMWH has also been shown to be a safe and effective treatment for confirmed deep vein thrombosis in pregnant women.

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- Adam J Duhl.
- Department of Obstetrics and Gynecology, Mercy Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. adamduhl@yahoo.com
- J Reprod Med. 2008 Sep 1; 53 (9): 657-66.
AbstractCertain pregnant populations are at high risk of developing venous thromboembolism (VTE) during pregnancy. Patients at particularly high risk of VTE are those with a history of VTE, thrombophilia or adverse pregnancy outcomes or with mechanical heart valves. In these high-risk patients, evidence-based guidelines recommend the use of thromboprophylaxis. Low-molecular-weight heparin (LMWH) is a safe and effective thromboprophylaxis option in these patients and has a number of administrative and pharmacokinetic advantages over unfractionated heparin. Furthermore, LMWH has also been shown to be a safe and effective treatment for confirmed deep vein thrombosis in pregnant women.

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Low-molecular-weight heparins for the prevention and treatment of venous thromboembolism in at-risk pregnant women: a review.

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