• Godfrey M Bigogo, Robert F Breiman, Daniel R Feikin, Allan O Audi, Barrack Aura, Leonard Cosmas, M Kariuki Njenga, Barry S Fields, Victor Omballa, Henry Njuguna, Peter M Ochieng, Daniel O Mogeni, George O Aol, Beatrice Olack, Mark A Katz, Joel M Montgomery, and Deron C Burton.
• International Emerging Infections Program.
• J. Infect. Dis. 2013 Dec 15; 208 Suppl 3: S207-16.

BackgroundInformation on the epidemiology of respiratory syncytial virus (RSV) infection in Africa is limited for crowded urban areas and for rural areas where the prevalence of malaria is high.MethodsAt referral facilities in rural western Kenya and a Nairobi slum, we collected nasopharyngeal/oropharyngeal (NP/OP) swab specimens from patients with influenza-like illness (ILI) or severe acute respiratory illness (SARI) and from asymptomatic controls. Polymerase chain reaction assays were used for detection of viral pathogens. We calculated age-specific ratios of the odds of RSV detection among patients versus the odds among controls. Incidence was expressed as the number of episodes per 1000 person-years of observation.ResultsBetween March 2007 and February 2011, RSV was detected in 501 of 4012 NP/OP swab specimens (12.5%) from children and adults in the rural site and in 321 of 2744 NP/OP swab specimens (11.7%) from those in the urban site. Among children aged <5 years, RSV was detected more commonly among rural children with SARI (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.2-3.3), urban children with SARI (OR, 8.5; 95% CI, 3.1-23.6), and urban children with ILI (OR, 3.4; 95% CI, 1.2-9.6), compared with controls. The incidence of RSV disease was highest among infants with SARI aged <1 year (86.9 and 62.8 episodes per 1000 person-years of observation in rural and urban sites, respectively).ConclusionsAn effective RSV vaccine would likely substantially reduce the burden of respiratory illness among children in rural and urban areas in Africa.

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