• Josefina López-Aguilar, Umberto Lucangelo, Guillermo M Albaiceta, Avi Nahum, Gastón Murias, Rosario Cañizares, Joan Carles Oliva, Pablo V Romero, and Lluís Blanch.
• Fundació Parc Taulí, Corporació Sanitària Parc Taulí, Sabadell, Spain; Institut de Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, Campus d' Excelència Internacional, Bellaterra, Spain; Critical Care Center, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jlopeza@tauli.cat.
• Respir Physiol Neurobiol. 2015 May 1; 210: 30-7.

AbstractWe determined whether the combination of low dose partial liquid ventilation (PLV) with perfluorocarbons (PFC) and prone positioning improved lung function while inducing minimal stress. Eighteen pigs with acute lung injury were assigned to conventional mechanical ventilation (CMV) or PLV (5 or 10 ml/kg of PFC). Positive end-expiratory pressure (PEEP) trials in supine and prone positions were performed. Data were analyzed by a multivariate polynomial regression model. The interplay between PLV and position depended on the PEEP level. In supine PLV dampened the stress induced by increased PEEP during the trial. The PFC dose of 5 ml/kg was more effective than the dose 10 ml/kg. This effect was not observed in prone. Oxygenation was significantly higher in prone than in supine position mainly at lower levels of PEEP. In conclusion, MV settings should take both gas exchange and stress/strain into account. When protective CMV fails, rescue strategies combining prone positioning and PLV with optimal PEEP should improve gas exchange with minimal stress.Copyright © 2015 Elsevier B.V. All rights reserved.

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