• Masui · Aug 2007

    [Propofol does not induce retrograde amnesia at the hypnotic dose].

    • Kazuyoshi Hashimoto, Takayuki Okada, and Norimasa Seo.
    • Department of Anesthesiology, Hanyu General Hospital, Hanyu 348-8505.
    • Masui. 2007 Aug 1; 56 (8): 920-4.

    BackgroundWe evaluated retrograde amnesic effects of propofol at the hypnotic dose on 28 healthy medical personnel volunteers (17 men, 11 women).MethodsExplicit memory function was measured after the emergence from bolus infusion of propofol 2 mg x kg(-1); how one could answer the correct number and symbol of 5 playing cards which he had picked up randomly and intentionally memorized before induction? As control, one also took the same test during working hour without any drugs.ResultsAfter infusion of propofol, the rate of correct answers was 96.4 +/- 9.1% and in control, it was 92.1 +/- 18.3% (P = 0.297142). There was no significant difference among two situations.ConclusionsThese results suggest that propofol dose not induce retrograde amnesia at hypnotic dose.

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