• Mozhgan Rezaei Kanavi, Atefeh Javadi, and Mohammad Ali Javadi.
• Ophthalmic Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mrezaie47@yahoo.com
• Eur J Ophthalmol. 2010 Sep 1; 20 (5): 839-43.

PurposeTo specify histopathologic and immunohistochemical features of chronic and delayed mustard gas keratopathy.MethodsCorneal buttons from patients with chronic and delayed mustard gas keratopathy were examined for routine histopathology, special histologic stainings, and immunohistochemistry for CD31 and CD68.ResultsTwenty-five corneal buttons from 25 patients with chronic and delayed mustard gas keratopathy were evaluated. Irregular epithelial thickness (100%), degenerative changes (24) (96%), thickened epithelial basement membrane (23) (92%), keratocytes loss (18) (72%), and destroyed Bowman layer (18) (72%) were predominant histopathologic features. Amyloid degeneration was the most commonly observed degenerative change in the specimens (83%). Immunoreactivity for CD68 and CD31 was detected in 88% and 56%, respectively.ConclusionsIn this observational case series, although all corneal layers from epithelium to the endothelium were involved from mild to severe degrees, the anterior corneal layers were more affected on histopathology than the posterior parts in chronic and delayed mustard gas keratopathy.

34 keywords...

hide…