• A R Towne, E J Waterhouse, J G Boggs, L K Garnett, A J Brown, J R Smith, and R J DeLorenzo.
• Department of Neurology, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0599, USA.
• Neurology. 2000 Jan 25; 54 (2): 340-5.

BackgroundNonconvulsive status epilepticus (NCSE) is a form of status epilepticus (SE) that is an often unrecognized cause of coma.ObjectiveTo evaluate the presence of NCSE in comatose patients with no clinical signs of seizure activity.MethodsA total of 236 patients with coma and no overt clinical seizure activity were monitored with EEG as part of their coma evaluation. This study was conducted during our prospective evaluation of SE, where it has been validated that we identify over 95% of all SE cases at the Medical College of Virginia Hospitals. Only cases that were found to have no clinical signs of SE were included in this study.ResultsEEG demonstrated that 8% of these patients met the criteria for the diagnosis of NCSE. The study included an age range from 1 month to 87 years.ConclusionThis large-scale EEG evaluation of comatose patients without clinical signs of seizure activity found that NCSE is an underrecognized cause of coma, occurring in 8% of all comatose patients without signs of seizure activity. EEG should be included in the routine evaluation of comatose patients even if clinical seizure activity is not apparent.

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