• Current drug targets · Mar 2006

    Review

    Clinical aspects of natural anti-angiogenic drugs.

    • C P Neal, D P Berry, H Doucas, M M Manson, W Steward, and G Garcea.
    • Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester, UK.
    • Curr Drug Targets. 2006 Mar 1; 7 (3): 371-83.

    AbstractNatural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived from varied species of plant, animal and micro-organism. Over a dozen of these agents have now entered clinical trial. This review discusses evidence for the efficacy of this drug class and key issues in the translation of pre-clinical results into the development of efficacious drugs for clinical use.

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