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Revue médicale de Liège · May 2012
Review[Vitamin D tweets light to genes in multiple sclerosis].
- E Lommers, L Lecrompe, G Moonen, R Phan-Ba, and S Belachew.
- MYelin Disorders REseArch teaM (MYDREAM), Liège, Belgique. elommers@chu.ulg.ac.be
- Rev Med Liege. 2012 May 1; 67 (5-6): 359-65.
AbstractThe relationship between sunlight exposure and the incidence of multiple sclerosis and the understanding of immunomodulatory effects of vitamin D triggered, in recent years, a broad range of investigations. Immunological studies performed in vitro and in vivo have demonstrated how tolerogenic vitamin D can be. Epidemiological studies confirmed an increased incidence of multiple sclerosis in vitamin D deficient subjects and signs of increased disease activity in such MS patients. Although small-scale observational studies have suggested a beneficial impact of vitamin D supplementation on the incidence and severity of multiple sclerosis, large scale clinical trials remain warranted to confirm these preliminary results.
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