• Science · Apr 2005

    H2S induces a suspended animation-like state in mice.

    • Eric Blackstone, Mike Morrison, and Mark B Roth.
    • Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
    • Science. 2005 Apr 22; 308 (5721): 518.

    AbstractMammals normally maintain their core body temperature (CBT) despite changes in environmental temperature. Exceptions to this norm include suspended animation-like states such as hibernation, torpor, and estivation. These states are all characterized by marked decreases in metabolic rate, followed by a loss of homeothermic control in which the animal's CBT approaches that of the environment. We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse (Mus musculus). This state is readily reversible and does not appear to harm the animal. This suggests the possibility of inducing suspended animation-like states for medical applications.

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