• R Norman Harden, Ann Louise Oaklander, Allen W Burton, Roberto S G M Perez, Kathryn Richardson, Melanie Swan, Jennifer Barthel, Brienne Costa, Joseph R Graciosa, Stephen Bruehl, and Reflex Sympathetic Dystrophy Syndrome Association.
• Center for Pain Studies, Rehabilitation Institute of Chicago, Illinois 60611, USA. nharden@ric.org
• Pain Med. 2013 Feb 1; 14 (2): 180-229.

ObjectiveThis is the fourth edition of diagnostic and treatment guidelines for complex regional pain syndrome (CRPS; aka reflex sympathetic dystrophy).MethodsExpert practitioners in each discipline traditionally utilized in the treatment of CRPS systematically reviewed the available and relevant literature; due to the paucity of levels 1 and 2 studies, less rigorous, preliminary research reports were included. The literature review was supplemented with knowledge gained from extensive empirical clinical experience, particularly in areas where high-quality evidence to guide therapy is lacking.ResultsThe research quality, clinical relevance, and "state of the art" of diagnostic criteria or treatment modalities are discussed, sometimes in considerable detail with an eye to the expert practitioner in each therapeutic area. Levels of evidence are mentioned when available, so that the practitioner can better assess and analyze the modality under discussion, and if desired, to personally consider the citations. Tables provide details on characteristics of studies in different subject domains described in the literature.ConclusionsIn the humanitarian spirit of making the most of all current thinking in the area, balanced by a careful case-by-case analysis of the risk/cost vs benefit analysis, the authors offer these "practical" guidelines.Wiley Periodicals, Inc.

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