• Osama M Assad, Ayman A El Sayed, and Mohamed A Khalil.
• Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: osamaasaad72@yahoo.com.
• J Clin Anesth. 2016 Nov 1; 34: 55-61.

Study ObjectiveTo analyze the effects of pressure-controlled ventilation-volume guaranteed (PCV-VG) and volume controlled ventilation (VCV) on airway pressures and respiratory and circulatory indicators during laparoscopic surgery in Trendelenburg position.DesignProspective randomized comparative clinical study.SettingTertiary hospital.PatientsForty ASA physical status 1 and 2 patients who underwent elective laparoscopic surgery in Trendelenburg position.InterventionsPatients were randomly allocated to either VCV group (n=20) or the PCV-VG group (n=20). After induction of anesthesia, for both modes of ventilation, the target tidal volume (VT) was 8mL/kg and the respiratory rate was adjusted to avoid hypercarbia.MeasurementsThe peak and mean inspiratory pressures, dynamic compliance, exhaled VT, oxygenation index and physiological dead space were calculated and recorded at T1, 5minutes after induction of anesthesia in supine position, T2, 5minutes after stabilization of pneumoperitoneum, T3 and T4, 15 and 60minutes after 30° Trendelenburg position with pneumoperitoneum respectively.Main ResultsPCV-VG group had significantly lower peak inspiratory pressure and greater dynamic compliance than VCV group (P<.001).ConclusionsIn patients who underwent laparoscopic surgery in Trendelenburg position, PCV-VG was superior to VCV in its ability to provide ventilation with lower peak inspiratory pressure and greater dynamic compliance.Copyright © 2016 Elsevier Inc. All rights reserved.

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