• The Journal of pediatrics · Jan 2016

    Comparative Study

    Not Just a Drop in the Bucket-Inversion of Oxymetazoline Nasal Decongestant Container Increases Potential for Severe Pediatric Poisoning.

    • Sean Patrick Nordt, Lisa E Vivero, and F Lee Cantrell.
    • Section of Toxicology, Department of Emergency Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address: spnordt@hotmail.com.
    • J. Pediatr. 2016 Jan 1; 168: 240-1.

    AbstractOxymetazoline is an over-the-counter nasal decongestant with potent alpha agonist properties. In overdoses as small as 1-2 mL, toxicity can be seen including bradycardia and respiratory depression. We demonstrated that inverting the container increased the volume delivered 20- to 30-fold compared with holding it upright in an in vitro model.Copyright © 2016 Elsevier Inc. All rights reserved.

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