• Ugeskrift for laeger · Jul 2014

    Review

    [Radium-223 treatment of bone metastases from castration-resistant prostate cancer].

    • Jann Mortensen and Liselotte Højgaard.
    • Klinik for Klinisk Fysiologi, Nuklearmedicin & PET, Rigshospitalet, Blegdamsvej 9, 2100 København Ø. liselotte.hoejgaard@rh.regionh.dk.
    • Ugeskr. Laeg. 2014 Jul 21; 176 (30): 1399-402.

    AbstractThe alpha emitter Radium-223 ((22)3Ra-Cl2) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone refractory prostate cancer. More than 1,000 patients have been included in clinical phase I-III tests showing significant reduction in alkaline phosphatase- and PSA level and prolonged survival. Adverse events are usually mild to moderate and comprise gastrointestinal and myelotoxic symptoms. Intravenously administered (22)3Ra-Cl2 (half-life 11.4 days) will likely be given every four weeks for six treatments to out-patients.

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