• B Nucci, Agm Aya, E Aubry, and J Ripart.
• Division of Anesthesiology, Pain, Emergency and Critical Care Medicine, Caremeau University Hospital, Nîmes, France. Electronic address: bastiannucci@gmail.com.
• J Clin Anesth. 2016 Dec 1; 35: 321-325.

Study ObjectiveThe aim of the study was to compare the incidence of the use of additional uterotonics before and after the change of carbetocin to oxytocin for the prevention of postpartum hemorrhage after cesarean delivery in women with severe preeclampsia.DesignThis was an observational retrospective before-and-after study.SettingOperating room, postoperative recovery area.PatientsSixty women with severe preeclampsia undergoing cesarean delivery under spinal anesthesia; American Society of Anesthesiologists 3.InterventionsObservational study.MeasurementsBlood pressure, heart rate, and biological data (hemoglobin, platelets, haptoglobin, prothrombin time index, activated partial thromboplastin time ratio, blood uric acid, aspartate aminotransferase, alanine aminotransferase, serum urea, serum creatinine, and albumin).Main ResultsThe incidence of additional uterotonic administration in the carbetocin and oxytocin groups was 15% and 10%, respectively (P=.70).ConclusionsAs carbetocin appears to be as effective and safe as oxytocin in preeclamptic women, its advantages make it a good uterotonic option in this particular setting.Copyright © 2016 Elsevier Inc. All rights reserved.

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