• The FEBS journal · Mar 2010

    Review

    Human telomeric G-quadruplex: structures of DNA and RNA sequences.

    • Anh Tuân Phan.
    • Division of Physics & Applied Physics, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore. phantuan@ntu.edu.sg
    • FEBS J. 2010 Mar 1; 277 (5): 1107-17.

    AbstractTelomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.

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