• Çağrı Kökoğlu, Emre Delen, Ali Arslantaş, Didem Arslantaş, Burcu Kökoğlu, Zühtü Özbek, Sema Uslu, and Ahmet Tolgay Akıncı.
• Department of Neurosurgery, Eskişehir Yunus Emre State Hospital, Eskişehir-Turkey.
• Ulus Travma Acil Cer. 2016 Nov 1; 22 (6): 521-525.

BackgroundThis experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI).MethodsThirty-five Sprague Dawley rats were distributed into 5 groups. First group was used for normal biochemical values. Spinal cord injury was induced in 4 remaining groups with clip compression technique after laminectomy process to T10 vertebra. Second group was designated solvent group and received 1 cc physiological serum after injury. Third group was medicated with intraperitoneal 2000 u/kg single dose erythropoietin after injury. Orogastric 2 mg/kg single dose tadalafil was administered to fourth group after injury. Fifth group did not receive any treatment and was used for biochemical values with injury. All subjects were sacrificed 48 hours after application. Malondialdehyde (MDA) and total antioxidant capacity (TAOC) values were evaluated using blood and tissue samples.ResultsLowest serum and tissue MDA values were found in group with erythropoietin intake. While highest serum TAOC values of all groups were seen in tadalafil group, highest tissue TAOC values were observed in group given erythropoietin.ConclusionIt was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.

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