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Ulus Travma Acil Cer · Nov 2016
The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study.
- İsmail Gülşen, Hakan Ak, Mikail Kara, Abdulsemat Gökalp, Veysel Akyol, Ömer Faruk Koçak, and Murat Çetin Rağbetli.
- Department of Neurosurgery, Yüzüncü Yıl University Faculty of Medicine, Van-Turkey. dr-ismailgulsen@hotmail.com.
- Ulus Travma Acil Cer. 2016 Nov 1; 22 (6): 526-530.
BackgroundThe purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury.MethodsA rat model of crush injury of the sciatic nerve was used. Animals were divided into 3 groups: control, trauma, and TQ treatment groups (n=6 per group). Seven days after injury, sciatic nerve specimens were obtained from the site of the injury and analyzed histologically and stereologically. Axon diameter, myelin thickness, and axon density were measured.ResultsThere were no significant differences in axon diameter, myelin thickness, or axon density among groups.ConclusionTQ has no acute therapeutic effect on acute nerve injury.
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