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- Andrew Moore, Philip Wiffen, and Eija Kalso.
- Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
- JAMA. 2014 Jul 1;312(2):182-3.
Clinical QuestionAre antiepileptic drugs associated with reduced pain intensity in patients with neuropathic pain or fibromyalgia?Bottom LineIn treating diabetic neuropathy and postherpetic neuralgia compared with placebo, gabapentin and pregabalin are associated with a modest increase in the number of patients experiencing meaningful pain reduction. In treating fibromyalgia, compared with placebo, pregabalin alone is associated with a small increase in the number of patients experiencing meaningful pain reduction. There is insufficient evidence for other antiepileptics.
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