• Pediatric dermatology · Jul 1996

    Case Reports

    Exfoliative dermatitis due to immunologically confirmed carbamazepine hypersensitivity.

    • R J Troost, A P Oranje, R L Lijnen, R Benner, and E P Prens.
    • Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
    • Pediatr Dermatol. 1996 Jul 1; 13 (4): 316-20.

    AbstractA 6-year-old Caucasian girl experienced a generalized erythematous skin rash during carbamazepine therapy. Over the next four days the eruption worsened into erythroderma with fever and generalized lymphadenopathy. Routine laboratory studies revealed increased serum levels of liver enzymes and eosinophilia. Immunologic reactivity to the anticonvulsant carbamazepine and its analogs was investigated both in vivo and in vitro by patch tests and lymphocyte proliferation assays, respectively.

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