• Maturitas · Oct 2011

    Recent advances in the therapy of castration-resistant prostate cancer: the price of progress.

    • Dhwanishiva Vasani, David Y Josephson, Courtney Carmichael, Oliver Sartor, and Sumanta Kumar Pal.
    • Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, United States. dhwanishiva@gmail.com
    • Maturitas. 2011 Oct 1; 70 (2): 194-6.

    AbstractWithin the past two years, three agents have garnered approval from the US FDA for the specific treatment of metastatic castration resistant prostate cancer (mCRPC) - (1) abiraterone, (2) cabazitaxel and (3) sipuleucel-T. In separate phase III studies, each agent led to an improvement in overall survival (OS) of 2-4 months over a suitable comparator. With these costly therapies all having potential application in the patient with mCRPC, multiple entities (industry, government, and the general public) must strategize to determine how the cost burden of these agents can be balanced with the potential gains for the individual patient. Herein, we provide a framework with which to approach this dilemma.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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