• J Perinatol · Jun 2003

    Case Reports

    Resolution of peripheral artery catheter-induced ischemic injury following prolonged treatment with topical nitroglycerin ointment in a newborn: a case report.

    • Pedro Vasquez, Angela Burd, Rajeev Mehta, Mark Hiatt, and Thomas Hegyi.
    • Department of Pediatrics/Neonatology, UMDNJ-Robert Wood Johnson Medical School, Saint Peter's University Hospital, New Brunswick, NJ 08901, USA.
    • J Perinatol. 2003 Jun 1; 23 (4): 348-50.

    AbstractTissue ischemia, necrosis, and gangrene are uncommon but well-described complications of arterial catheterization in the neonate. Treatment options for progressive tissue necrosis following arterial embolization and/or vasospasm are limited in these patients secondary to unpredictable pharmacokinetics and risks associated with systemic anticoagulation or vasodilatation in newborns. We report a case of a multidose regimen of topical 2% nitroglycerin ointment for reversing severe tissue ischemia following peripheral arterial line placement. The favorable response in this infant suggests that topical nitroglycerin therapy should be considered as potential therapy to ameliorate the effects of vascular compromise following arterial line placement in neonates.

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