• Neurology · Oct 2006

    Case Reports

    Response of intrathecal baclofen resistance to dose reduction.

    • Joanna A Cooper and Barbara Ridley.
    • Spasticity Management Program, Alta Bates Summit Medical Center, Berkeley, CA, USA. Cooperj2@sutterhealth.org
    • Neurology. 2006 Oct 24; 67 (8): 1495-6.

    AbstractDose stabilization of intrathecal baclofen (ITB) is usually achieved within 6 to 18 months. In some patients, an increase in ITB dose may result in paradoxical unresponsiveness to baclofen. We present two cases demonstrating increased tone and functional decline with increasing ITB doses after a period of clinical stability. In both cases, reduction of ITB dose was associated with marked clinical improvement.

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